C3-Bio
C3-Bio

Bioanalysis Services in Partnership with Avantia Labs-GLP/GCP Compliant Lab

Bioanalysis Services in Partnership with Avantia Labs-GLP/GCP Compliant LabBioanalysis Services in Partnership with Avantia Labs-GLP/GCP Compliant LabBioanalysis Services in Partnership with Avantia Labs-GLP/GCP Compliant Lab

We offer a comprehensive range of services including anti-AAV antibody screening, Anti-AAV ELISA kits, and specialized ddPCR services, along with ELISpot assays.

Bioanalysis Services in Partnership with Avantia Labs-GLP/GCP Compliant Lab

Bioanalysis Services in Partnership with Avantia Labs-GLP/GCP Compliant LabBioanalysis Services in Partnership with Avantia Labs-GLP/GCP Compliant LabBioanalysis Services in Partnership with Avantia Labs-GLP/GCP Compliant Lab

We offer a comprehensive range of services including anti-AAV antibody screening, Anti-AAV ELISA kits, and specialized ddPCR services, along with ELISpot assays.

Innovative AAV and CAR-T Cell Therapy Services

Colorful 3D molecular virus structures against a dark, abstract background.

Anti-AAV serotype-specific antibody screening services

Our team of experts tirelessly develops and validates new Anti-AAV ELISA kits as listed below for anti-AAV antibody screening, specifically designed to detect anti-AAV serotype antibodies under high-stringency conditions in the serum/plasma of humans, monkeys, minipigs, and other species with high sensitivity, simplicity, and specificity. We utilize state-of-the-art technology and cutting-edge research techniques to create these test kits for preclinical and clinical research. Additionally, we can collaborate with CLIA Lab to develop lab-developed kits and Companion Diagnostics kits. Our Anti-AAV antibody ELISA kits include serotypes AAV1, 2, 5, 6, 8, 9, rh74, or custom-provided AAV variant vectors, and we also offer ddPCR services to enhance your research capabilities.

Anti-AAV serotype-specific antibody MSD Bridging assay kits

We have developed MSD bridging-based AAV antibody assays for anti-AAV antibody screening across AAV1, 2, 5, 6, 8, 9, and rh74 serotypes. Additionally, we offer Anti-AAV ELISA kits and ddPCR services to support your research needs. Refer to our publication 2 below.

AAV serotype antibody Chemiluminescence Bridging assay kits

We have developed Chemiluminescence Bridging-based anti-AAV antibody assays for AAV1, 2, 5, 6, 8, 9, and rh74 serotypes, which can also be used for anti-AAV antibody screening. 

Anti-AAV serotype-specific neutralizing antibody assay services

We have developed cell-based anti-AAV neutralizing antibody assays for AAV1, 2, 5, 6, 8, 9, and rh74 serotypes, which are used for anti-AAV neutralizing antibody screening. 

ddPCR assay for gene expression, CAR-T CK copy number assay

Our team specializes in ddPCR services to develop assays that quantify gene expression, alongside a Replication-Competency assay for cell and gene therapies targeting a variety of diseases.

ELISpot Assay to detect CD8 cytotoxic T cell immunity

We are focused on developing the ELISpot assay to detect T cell immunity, which is essential for advancing gene and cell therapy.

AAV titer and empty/full assay using Unchained Stunner instrument

We utilize Stunner from Unchained Labs to detect AAV vector titer, identify empty/full AAV vectors, and evaluate AAV vector aggregation.

Publications

  • 1. Comparison of pre-existing anti-AAV antibody screening and confirmatory assays with a cell-based neutralizing assay in normal human serum. AAPS J. 2023 Apr 3;25(3):35. doi: 10.1208/s12248-023-00805-6.PMID: 37012501. 
  • https://link.springer.com/article/10.1208/s12248-023-00805-6
  • 2. Determining the degree of sulfo-tag conjugation to AAV5 vectors by LC-HRMS and evaluating the effects on antibody binding affinity and bridging assay sensitivity. AAPS J. 2024 Sep 16;26(6):104. doi: 10.1208/s12248-024-00970-2. 
  • https://link.springer.com/article/10.1208/s12248-024-00970-2
  • 3. Biacore analysis of cross-reactive adeno-associated virus antibodies in monkeys following intravenous administration of AAV5, AAV8, and AAV9 vectors. Hum Gene Ther. 2025 Aug 29. doi: 10.1177/10430342251374689. 
  • https://www.liebertpub.com/doi/10.1177/10430342251374689
  • 4. Prevalence of pre-existing neutralizing antibodies against adeno-associated virus serotypes 1, 2, 5, 6, 8, and 9 in sera of different pig strains. Hum Gene Ther. 2022 Apr;33(7-8):451-459. doi: 10.1089/hum.2021.213. 
  • https://www.liebertpub.com/doi/10.1089/hum.2021.213
  • 5. Monitoring antigen-specific cellular immune response using an RT-ddPCR-based assay for IFN-γ gene expression highlights the importance of ddPCR services in evaluating immune responses. J Pharm Sci. 2025 Feb;114(2):1017-1023. doi: 10.1016/j.xphs.2024.11.009. Epub 2024 Nov 26. 
  • https://jpharmsci.org/article/S0022-3549(24)00514-8/abstract
  • 6. Bioanalytical methods for characterization of CAR-T cellular kinetics: comparison of PCR assays and matrices. Clin Pharmacol Ther. 2023 Sep;114(3):664-672. doi: 10.1002/cpt.2991. 
  • https://ascpt.onlinelibrary.wiley.com/doi/10.1002/cpt.2991

Learn More

Contact Us: info@c3-bio.com; Phone: 215-279-5832

We love our customers and invite you to visit during normal business hours to learn more about our anti-AAV antibody screening services and discover our ddPCR services.

https://avantialabs.com/

C3-Bio, LLC, an affiliate of Avantia Labs, Inc.

206 Welsh Road, Horsham, PA, USA

215-279-5832

Email: info@c3-bio.com

Open today

09:00 am – 05:00 pm

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C3-Bio, LLC, An Affiliate of Avantia Labs, Inc

206 Welsh Road, Horsham, PA, USA

215-279-5832

Copyright © 2025 C3-Bio - All Rights Reserved.

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